Article
Unravelling high density lipoprotein-apolipoprotein metabolism in human mutants and animal models.
Current opinion in lipidology - 1 Jun 1996
Rader D J, Ikewaki K
Abstract excerpt
Apolipoprotein A-I plays an essential structural and functional role in HDL metabolism and apolipoprotein A-II has important effects on HDL metabolism and function. Kinetic studies in humans have established that variation in plasma HDL-cholesterol and apolipoprotein A-I concentrations is primarily determined by variation in the rate of apolipoprotein A-I catabolism. In contrast, plasma apolipoprotein A-II levels...
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