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Article

A dual prognostic role for the TGFβ receptors in human breast cancer.

Human pathology - 1 Nov 2016

Hachim Ibrahim Y, Hachim Mahmood Y, López-Ozuna Vanessa M, Ali Suhad, Lebrun Jean-Jacques

Abstract excerpt

The transforming growth factor-β (TGFβ) plays a dual role in breast cancer, acting as a tumor suppressor in early carcinomas while promoting tumor metastasis in more advanced breast carcinoma. As a result, the prognostic role of TGFβ and its signaling components in breast cancer remains unclear. Here we evaluated the expression levels of TGFβ signaling receptors TβRII and TβRI using human breast cancer tissue...

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Identifiers

PMID: 27445263
DOI: 10.1016/j.humpath.2016.07.002

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