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Article

Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway

2 Mar 2022

Abstract excerpt

BRCA1 deficient breast cancers are aggressive and chemoresistant due, in part, to their enrichment of cancer stem cells that can be generated from carcinoma cells by an epithelial-mesenchymal transition (EMT). We previously discovered that BRCA1 deficiency activates EMT in mammary tumorigenesis. How BRCA1 controls EMT and how to effectively target BRCA1-deficient cancers remain elusive. We analyzed murine and...

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PMID: 35236825
DOI: 10.1038/s41419-022-04646-7

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