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Article

β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease.

Antimicrobial agents and chemotherapy - 1 Aug 2014

Bæk Kristoffer T, Gründling Angelika, Mogensen René G, Thøgersen Louise, Petersen Andreas, Paulander Wilhelm, Frees Dorte

Abstract excerpt

Methicillin-resistant Staphylococcus aureus (MRSA) has acquired the mecA gene encoding a peptidoglycan transpeptidase, penicillin binding protein 2a (PBP2a), which has decreased affinity for β-lactams. Quickly spreading and highly virulent community-acquired (CA) MRSA strains recently emerged as a frequent cause of infection in individuals without exposure to the health care system. In this study, we found that...

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Identifiers

PMID: 24867990
DOI: 10.1128/AAC.02802-14
PMCID: PMC4136064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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