Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to β-lactam antibiotics.

Abstract excerpt

Resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus is mediated by the mecA-encoded, β-lactam-resistant transpeptidase, penicillin-binding protein 2a (PBP2a), which is capable of crosslinking peptidoglycan in the presence of β-lactam antibiotics. Here, we report that mutation of the lipoprotein signal peptidase II gene, lspA, from the lipoprotein processing pathway, significantly...

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