Article
Mapping the HLA diversity of the Iberian Peninsula.
Human immunology - 1 Oct 2016
Romòn Iñigo, Montes Carmen, Ligeiro Dario, Trindade Hélder, Sanchez-Mazas Alicia, Nunes José Manuel, Buhler Stéphane
Abstract excerpt
The polymorphism of HLA genes can be used to reconstruct human peopling history. However, this huge diversity impairs successful matching in stem cell transplantation, a situation which has led to the recruitment of millions of donors worldwide. In parallel to the increase of recruitment, registries are progressively relying on information from population genetics to optimize their donor pools in terms of HLA...
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