Mapping the HLA diversity of the Iberian Peninsula.

doi:10.1016/j.humimm.2016.06.023

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Article

Mapping the HLA diversity of the Iberian Peninsula.

Human immunology - 1 Oct 2016

Romòn Iñigo, Montes Carmen, Ligeiro Dario, Trindade Hélder, Sanchez-Mazas Alicia, Nunes José Manuel, Buhler Stéphane

Abstract excerpt

The polymorphism of HLA genes can be used to reconstruct human peopling history. However, this huge diversity impairs successful matching in stem cell transplantation, a situation which has led to the recruitment of millions of donors worldwide. In parallel to the increase of recruitment, registries are progressively relying on information from population genetics to optimize their donor pools in terms of HLA...

Topics

Gene Frequency
Genotype
HLA Antigens
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Polymorphism, Genetic
Registries
Spain
Tissue Donors

Source

Open in PubMed

Identifiers

PMID: 27377016
DOI: 10.1016/j.humimm.2016.06.023

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