Article
Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 15 Sept 2014
Dahm Paul H, Richards Jeremy B, Karmouty-Quintana Harry, Cromar Kevin R, Sur Sanjiv, Price Roger E, Malik Farhan, Spencer Chantal Y, Barreno Ramon X, Hashmi Syed S, Blackburn Michael R, Haque Ikram U, Johnston Richard A
Abstract excerpt
Atopic, obese asthmatics exhibit airway obstruction with variable degrees of eosinophilic airway inflammation. We previously reported that mice obese as a result of a genetic deficiency in either leptin (ob/ob mice) or the long isoform of the leptin receptor (db/db mice) exhibit enhanced airway o...
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