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Article

A high-fat diet is associated with altered adipokine production and a more aggressive esophageal adenocarcinoma phenotype in vivo.

The Journal of thoracic and cardiovascular surgery - 1 Apr 2015

Fowler Aaron J, Richer Amanda L, Bremner Ross M, Inge Landon J

Abstract excerpt

OBJECTIVE: Obesity has been linked to esophageal adenocarcinoma (EAC). We hypothesize that adipokines, which are altered by obesity, could affect EAC growth rates and potentially serve as biomarkers of disease and targets for treatment. We have developed a potential murine model to investigate the effects of obesity-altered adipokines on EAC in vivo. METHODS: Severe combined immune-deficient mice were fed either...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25595377
DOI: 10.1016/j.jtcvs.2014.11.076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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