Article
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
Nature genetics - 1 Oct 2005
Harvey Natasha L, Srinivasan R Sathish, Dillard Miriam E, Johnson Nicole C, Witte Marlys H, Boyd Kelli, Sleeman Mark W, Oliver Guillermo
Abstract excerpt
Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.