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Article

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.

Human molecular genetics - 1 Oct 2014

Cornelissen Tom, Haddad Dominik, Wauters Fieke, Van Humbeeck Cindy, Mandemakers Wim, Koentjoro Brianada, Sue Carolyn, Gevaert Kris, De Strooper Bart, Verstreken Patrik, Vandenberghe Wim

Abstract excerpt

Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most frequent cause of recessive Parkinson's disease (PD). Parkin translocates from the cytosol to depolarized mitochondria, ubiquitinates outer mitochondrial membrane proteins and induces selective aut...

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Source

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Identifiers

PMID: 24852371
DOI: 10.1093/hmg/ddu244
PMCID: PMC7108632

Genes

USP15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24852371-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.PMID 24852371Read ↗

USP14 inhibition enhances Parkin-independent mitophagy in iNeuronsSemantic proximity Read ↗

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.Semantic proximity Read ↗

USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human NeuronsSemantic proximity Read ↗

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neuronsSemantic proximity Read ↗

USP8 inhibition promotes Parkin-independent mitophagy in the <i>Drosophila</i> brain and in human neuronsSemantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivoSemantic proximity Read ↗

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in DrosophilaSemantic proximity Read ↗

Parkinson's disease-associated proteins : studying their role in mitophagy with cellular and Drosophila modelsSemantic proximity Read ↗

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient and CCCP-stressed human iPSC-derived neuronsSemantic proximity Read ↗

USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkinSemantic proximity Read ↗

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provides a target for Pink1 phosphorylation <i>in vivo</i>Semantic proximity Read ↗

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in miceSemantic proximity Read ↗

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