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Article

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

29 May 2018

Abstract excerpt

Mutations in the genes for PINK1 and parkin cause Parkinson’s disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells. However, evidence for their role in mitophagy in vivo is still scarce. Here, we generated a Drosophila model expressing the mitophagy probe mt-Keima. Using live mt-Keima imaging and correlative light and electron microscopy...

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PMID: 29809156
DOI: 10.7554/elife.35878

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Deficiency of parkin and PINK1 impairs age-dependent mitophagy in DrosophilaPMID 29809156Read ↗

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