Parkinson's disease-associated proteins : studying their role in mitophagy with cellular and Drosophila models

Abstract excerpt

Parkinson's Disease (PD) is the second most common neurodegenerative disease, for which there is no effective treatment or biomarker. In about 10% of the cases PD is caused by mutations in PD-associated genes. Amongst these genes, the E3 ubiquitin-ligase Parkin and the Ser/Thr kinase PINK1 have been reported to act in a common pathway as key regulators of mitophagy, a selective type of autophagy where mitochondria...

Topics

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• Autophagy in Disease and Therapy
• Mitochondria
• Mitochondrial Function and Pathology
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments
• Ubiquitin and proteasome pathways
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

5b9ee3b3-81b7-5c28-a8d6-ac8968454d7a

DOI

10.17638/03007480