USP8 inhibition promotes Parkin-independent mitophagy in the <i>Drosophila</i> brain and in human neurons

Abstract excerpt

Stress-induced mitophagy, a tightly regulated process that targets dysfunctional mitochondria for autophagy-dependent degradation, mainly relays on two proteins, PINK1 and Parkin, which genes are mutated in some forms of familiar Parkinson’s Disease (PD). Upon mitochondrial damage, the protein kinase PINK1 accumulates on the organelle surface where it controls the recruitment of the E3-ubiquitin ligase Parkin. On...

Topics

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• Autophagy in Disease and Therapy
• Endoplasmic Reticulum Stress and Disease
• Lysosomal Storage Disorders Research
• Mitochondrial Function and Pathology
• Nuclear Receptors and Signaling
• Parkinson's Disease Mechanisms and Treatments
• Sirtuins and Resveratrol in Medicine
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

2db3d3c5-36a8-542c-8f24-875a295127e6

DOI

10.1101/2023.01.30.526170