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Article

BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization

15 May 2014

Abstract excerpt

We recently reported that BAG6/BAT3 (BCL2-associated athanogene 6) is essential for basal and starvation-induced autophagy in E18.5 bag6(-/-) mouse embryos and in mouse embryonic fibroblasts (MEFs) through the modulation of the EP300/p300-dependent acetylation of TRP53 and autophagy-related (ATG) proteins. We observed that BAG6 increases TRP53 acetylation during starvation and pro-autophagic TRP53-target gene...

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PMID: 24852146
DOI: 10.4161/auto.28979

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