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Article

Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

Molecular biology of the cell - 15 Apr 2010

Kong Derek K, Georgescu Serban P, Cano Carla, Aronovitz Mark J, Iovanna Juan Lucio, Patten Richard D, Kyriakis John M, Goruppi Sandro

Abstract excerpt

Autophagy is a cytoprotective pathway used to degrade and recycle cytoplasmic content. Dysfunctional autophagy has been linked to both cancer and cardiomyopathies. Here, we show a role for the transcriptional regulator p8 in autophagy. p8 RNA interference (RNAi) increases basal autophagy markers in primary cardiomyocytes, in H9C2 and U2OS cells, and decreases cellular viability after autophagy induction. This...

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Identifiers

PMID: 20181828
DOI: 10.1091/mbc.e09-09-0818
PMCID: PMC2854092

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