Article
Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.
The Journal of biological chemistry - 12 Jul 2013
Krenciute Giedre, Liu Shangfeng, Yucer Nur, Shi Yi, Ortiz Priscilla, Liu Qiongming, Kim Beom-Jun, Odejimi Abiola Ore, Leng Mei, Qin Jun, Wang Yi
Abstract excerpt
BCL2-associated athanogene 6 (BAG6) is a member of the BAG protein family, which is implicated in diverse cellular processes including apoptosis, co-chaperone, and DNA damage response (DDR). Recently, it has been shown that BAG6 forms a stable complex with UBL4A and GET4 and functions in membrane protein targeting and protein quality control. The BAG6 sequence contains a canonical nuclear localization signal and...
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