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A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons

20 Jun 2013

Abstract excerpt

Valproic acid (VPA) is a branched-chain saturated fatty acid with a long history of clinical use as an antiepileptic drug (AED). VPA is also known to inhibit histone deacetylases (HDACs) and to cause diverse effects on neural progenitor cells (NPCs) and neurons. Although the neuroprotective or neurodestructive effects of VPA have been investigated in heterogeneous cell populations, in this study, we used...

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PMID: 23788034
DOI: 10.1038/cddis.2013.205

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