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Article

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells.

British journal of cancer - 28 Feb 2005

Stockhausen M-T, Sjölund J, Manetopoulos C, Axelson H

Abstract excerpt

Neuroblastoma (NB), a sympathetically derived childhood tumour, shows characteristics of neuronal precursor cells, suggesting a halted differentiation process. We have previously shown that the Notch signalling cascade, a key player during normal neurogenesis, also might be involved in NB differentiation. Valproic acid (VPA), a well-tolerated antiepileptic drug, has been shown to induce differentiation and cell...

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Identifiers

PMID: 15685243
DOI: 10.1038/sj.bjc.6602309
PMCID: PMC2361888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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