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Article

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres

2024-09-24

Abstract excerpt

Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts partially by inhibiting histone deacetylases (HDACs) and could be repurposed as an epigenetic anticancer therapy. Here, we show that VPA reduced medulloblastoma (MB) cell viability...

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Literature Corpus work
b6a326b2-eb77-5045-886b-ee10bb2a5cb4
DOI
10.1101/2024.09.23.614476
Open publication

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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma NeurospheresDOI 10.1101/2024.09.23.614476
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