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Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury

5 Aug 2009

Abstract excerpt

Inflammatory cytokines are evoked by acute kidney injury (AKI) and may contribute to evolving renal disease. However, the impact of AKI-induced uremia on proinflammatory (e.g., TNF-alpha, MCP-1, TGF-beta1) and anti-inflammatory (e.g., IL-10) cytokine gene expression remains unknown. This study was undertaken to gain some initial insights into this issue. CD-1 mice were subjected to left renal ischemia-reperfusion...

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PMID: 19656911
DOI: 10.1152/ajprenal.00381.2009

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