Article
A comprehensive association analysis of homocysteine metabolic pathway genes in Singaporean Chinese with ischemic stroke.
PloS one - 1 Jan 2011
Low Hui-Qi, Chen Christopher P L H, Kasiman Katherine, Thalamuthu Anbupalam, Ng Seok-Shin, Foo Jia-Nee, Chang Hui-Meng, Wong Meng-Cheong, Tai E-Shyong, Liu Jianjun
Abstract excerpt
BACKGROUND: The effect of genetic factors, apart from 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms, on elevated plasma homocysteine levels and increasing ischemic stroke risk have not been fully elucidated. We conducted a comprehensive analysis of 25 genes involved in homocysteine metabolism to investigate association of common variants within these genes with ischemic stroke risk....
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