Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and ischemic stroke in Tunisian patients.

doi:10.1016/j.jstrokecerebrovasdis.2013.03.011

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Article

Methylenetetrahydrofolate reductase (C677T and A1298C) polymorphisms, hyperhomocysteinemia, and ischemic stroke in Tunisian patients.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 May 2013

Fekih-Mrissa Najiba, Mrad Meriem, Klai Sarra, Mansour Malek, Nsiri Brahim, Gritli Nasreddine, Mrissa Ridha

Abstract excerpt

OBJECTIVE: The present study evaluated the role of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms and correlated these results with plasma homocysteine (Hcy) levels in Tunisian ischemic stroke (IS) patients. METHODS: Overall, 84 patients with IS were included and compared with 100 healthy controls. The most common stroke risk factors were investigated. Fasting plasma Hcy...

Topics

Adult
Aged
Biomarkers
Brain Ischemia
Case-Control Studies
Chi-Square Distribution
Female
Genetic Predisposition to Disease
Homocysteine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hyperhomocysteinemia

Male

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Odds Ratio

Phenotype

Polymorphism, Genetic

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 23642756
DOI: 10.1016/j.jstrokecerebrovasdis.2013.03.011

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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