The complement system in systemic lupus erythematosus: an update.

doi:10.1136/annrheumdis-2014-205287

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Article

The complement system in systemic lupus erythematosus: an update.

Annals of the rheumatic diseases - 1 Sept 2014

Leffler Jonatan, Bengtsson Anders A, Blom Anna M

Abstract excerpt

The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently...

Topics

Adaptive Immunity
Apoptosis
Complement C1q
Complement Inactivator Proteins
Complement System Proteins
Genetic Predisposition to Disease
Humans
Lupus Erythematosus, Systemic
Mutation
Receptors, Complement

Source

Open in PubMed

Identifiers

PMID: 24845390
DOI: 10.1136/annrheumdis-2014-205287

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