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Article

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

15 Feb 2016

Abstract excerpt

The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated tissue injury, most notably systemic lupus erythematosus (SLE). Paradoxically, a complete deficiency of an early component of the CP, as evidenced by homozygous...

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PMID: 26913032
DOI: 10.3389/fimmu.2016.00036

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