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Article

Complement deficiencies in humans and animals: Links to autoimmunity

1 Jan 2006

Abstract excerpt

Complement is involved in the pathogenesis of systemic lupus erythematosus (SLE) in multiple ways and may act as both friend and foe. Inherited homozygous deficiency of one of the earliest components of the classical pathway is strongly associated with susceptibility to the development of SLE. However, complement is also implicated in the effector inflammatory phase of the autoimmune response that characterizes...

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PMID: 16923536
DOI: 10.1080/08916930600739233

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Source receipt: pubmed, retrieved 7 Sept 2026.

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