Review: The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases

Abstract excerpt

The complement system is increasingly understood to play major roles in the pathogenesis of human inflammatory and autoimmune diseases. Because of this situation, there are rapidly expanding commercial efforts to develop novel complement inhibitors and effector pathway-modulating drugs. This review provides insights into the evolving understanding of the complement system components, mechanisms of activation...

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