SLE and Serum Complement: Causative, Concomitant or Coincidental?

Abstract excerpt

BACKGROUND: Systemic Lupus Erythematosus (SLE) is an incurable autoimmune disorder with complement activation playing a key role in the pathogenesis of immune-mediated tissue injury. While quantifying complement to monitor SLE disease activity has been the standard of care since the 1950s, decreased complement levels are not consistently associated with flares. OBJECTIVE: We seek to clarify the SLE phenotype in...

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