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Article

The complement system in lupus nephritis

2015-06-08

Abstract excerpt

The complement is part of the innate immune system and can be activated through one of three pathways. To prevent injury of self-tissue, complement is tightly regulated by over 30 proteins. Complement plays dual roles in the pathogenesis of systemic lupus erythematosus (SLE). On one hand, hereditary homozygous deficiencies of classical pathway components, such as C1q and C4, are associated with an increased risk f...

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Literature Corpus work
7e7db898-5425-5fa7-bcb6-9ef1314eede8
DOI
10.12688/f1000research.6562.1
Open publication

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