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Article

A functional framework for interpretation of genetic associations in T1D.

Current opinion in immunology - 1 Oct 2012

Nepom Gerald T, Buckner Jane H

Abstract excerpt

Susceptibility to type 1 diabetes is attributable to genes that link disease progression to distinct steps in immune activation, expansion, and regulation. Recent studies illustrate examples of disease-associated variants that function in multiple cell types and independent pathways, some that impact different steps of a single mechanistic pathway, and some that are functionally interactive for deterministic...

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Share to Diabetes Mellitus, Type 1
Share to Genetic Association Studies
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Immunity, Cellular

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Source

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Identifiers

PMID: 22841349
DOI: 10.1016/j.coi.2012.07.003
PMCID: PMC4260931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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