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Article

Changes in gene expression associated with FTO overexpression in mice.

PloS one - 1 Jan 2014

Merkestein Myrte, McTaggart James S, Lee Sheena, Kramer Holger B, McMurray Fiona, Lafond Mathilde, Boutens Lily, Cox Roger, Ashcroft Frances M

Abstract excerpt

Single nucleotide polymorphisms in the first intron of the fat-mass-and-obesity-related gene FTO are associated with increased body weight and adiposity. Increased expression of FTO is likely underlying this obesity phenotype, as mice with two additional copies of Fto (FTO-4 mice) exhibit increased adiposity and are hyperphagic. FTO is a demethylase of single stranded DNA and RNA, and one of its targets is the...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

Share to Mixed Function Oxygenases

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Source

Open in PubMed Open full text

Identifiers

PMID: 24842286
DOI: 10.1371/journal.pone.0097162
PMCID: PMC4026227

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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