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Article

FTO and obesity: mechanisms of association.

Current diabetes reports - 1 Jan 2014

Zhao Xu, Yang Ying, Sun Bao-Fa, Zhao Yong-Liang, Yang Yun-Gui

Abstract excerpt

The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gene are associated not only with human adiposity and metabolic disorders, but also with cancer, a highly...

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Share to Epigenesis, Genetic
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Share to Mixed Function Oxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oxo-Acid-Lyases

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Source

Identifiers

PMID: 24627050
DOI: 10.1007/s11892-014-0486-0

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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FTO and obesity: mechanisms of association.PMID 24627050Read ↗

FTO as an epigenetic regulator in metabolic and inflammatory diseasesSemantic proximity Read ↗

The biology of FTO: from nucleic acid demethylase to amino acid sensor.Semantic proximity Read ↗

The Clinical Relevance of FTO as a Demethylase Beyond Cancer: Molecular Mechanisms and Therapeutic Opportunities.Semantic proximity Read ↗

The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.Semantic proximity Read ↗

The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.Semantic proximity Read ↗

Role of FTO in Adipocyte Development and Function: Recent InsightsSemantic proximity Read ↗

FTO variants are associated with ANGPTL4 abundances and correlated with body weight reduction after bariatric surgery.Semantic proximity Read ↗

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome.Semantic proximity Read ↗

Fine-Scale Haplotype Mapping Reveals Association of Fto Gene with Osteoporosis and Fracture Risk in Postmenopausal WomenSemantic proximity Read ↗

The genetics of obesity: FTO leads the way.Semantic proximity Read ↗

FTO gene affects obesity and breast cancer through similar mechanisms: A new insight into the molecular therapeutic targetsSemantic proximity Read ↗

FTO associations with obesity and telomere length.Semantic proximity Read ↗

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