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Article

FTO variants are associated with ANGPTL4 abundances and correlated with body weight reduction after bariatric surgery.

Obesity research & clinical practice - 1 Jan 2000

Wang Chao-Yung, Liu Keng-Hau, Tsai Ming-Lung, Ho Ming-Yun, Yeh Jih-Kai, Hsieh I-Chang, Wen Ming-Shien, Yeh Ta-Sen

Abstract excerpt

BACKGROUND: The FTO (fat mass- and obesity-associated) gene variant is an established obesity-susceptibility locus. FTO protein is a nucleic acid demethylase and FTO genetic variants form long-range functional connections with IRX3, which regulates fat mass and metabolism in humans. From our previous results, we found FTO regulates the metabolism of triglyceride in adipocytes through demethylating Angptl4...

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Adipose Tissue
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Bariatric Surgery
Body Mass Index
Obesity, Morbid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32507396
DOI: 10.1016/j.orcp.2020.05.002

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