Article
Stromal cell-derived factor-1 chemokine gene variant in blood donors and chronic myelogenous leukemia patients.
Journal of clinical laboratory analysis - 1 Jan 2007
de Oliveira Carlos Eduardo Coral, Cavassin Gabriela Gonçalves de Oliveira, Perim Aparecida de Lourdes, Nasser Thiago Franco, de Oliveira Karen Brajão, Fungaro Maria Helena Pelegrinelli, Carneiro Juliana Laino do Val, Watanabe Maria Angelica Ehara
Abstract excerpt
Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disorder that originates from a pluripotent stem cell expressing the bcr-abl oncogene. It is characterized by an abnormal release of the expanded, malignant stem cell clone from the bone marrow into the circulation. The stromal cell derived factor-1 (SDF-1) gene contains a common polymorphism, termed SDF1-3'A, in an evolutionarily conserved...
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