Article
Generation of a monkey with MECP2 mutations by TALEN-based gene targeting.
Neuroscience bulletin - 1 Jun 2014
Liu Zhen, Zhou Xue, Zhu Ying, Chen Zhi-Fang, Yu Bin, Wang Yan, Zhang Chen-Chen, Nie Yan-Hong, Sang Xiao, Cai Yi-Jun, Zhang Yue-Fang, Zhang Chen, Zhou Wen-Hao, Sun Qiang, Qiu Zilong
Abstract excerpt
Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey (Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases (TALENs)-mediated gene targeting. After injecting TALENs mRNA into monkey zygotes achieved by in vitro fertilization and embryo transplantation into surrogate...
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