Article
TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.
Cell research - 1 Sept 2016
Ke Qiong, Li Weiqiang, Lai Xingqiang, Chen Hong, Huang Lihua, Kang Zhuang, Li Kai, Ren Jie, Lin Xiaofeng, Zheng Haiqing, Huang Weijun, Ma Yunhan, Xu Dongdong, Chen Zheng, Song Xinming, Lin Xinyi, Zhuang Min, Wang Tao, Zhuang Fengfeng, Xi Jianzhong, Mao Frank Fuxiang, Xia Huimin, Lahn Bruce T, Zhou Qi, Yang Shihua, Xiang Andy Peng
Abstract excerpt
Gene editing in non-human primates may lead to valuable models for exploring the etiologies and therapeutic strategies of genetically based neurological disorders in humans. However, a monkey model of neurological disorders that closely mimics pathological and behavioral deficits in humans has not yet been successfully generated. Microcephalin 1 (MCPH1) is implicated in the evolution of the human brain, and MCPH1...
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