Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.

doi:10.1016/j.stem.2016.06.003

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Article

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.

Cell stem cell - 7 Jul 2016

Sato Kenya, Oiwa Ryo, Kumita Wakako, Henry Rachel, Sakuma Tetsushi, Ito Ryoji, Nozu Ryoko, Inoue Takashi, Katano Ikumi, Sato Kengo, Okahara Norio, Okahara Junko, Shimizu Yoshihisa, Yamamoto Masafumi, Hanazawa Kisaburo, Kawakami Takao, Kametani Yoshie, Suzuki Ryuji, Takahashi Takeshi, Weinstein Edward J, Yamamoto Takashi, Sakakibara Yasubumi, Habu Sonoko, Hata Jun-Ichi, Okano Hideyuki, Sasaki Erika

Abstract excerpt

Recent advances in genome editing have facilitated the generation of nonhuman primate (NHP) models, with potential to unmask the complex biology of human disease not revealed by rodent models. However, their broader use is hindered by the challenges associated with generation of adult NHP models as well as the cost of their production. Here, we describe the generation of a marmoset model of severe combined...

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PMID: 27374787
DOI: 10.1016/j.stem.2016.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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