Article
Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys.
Cell - 18 May 2017
Chen Yongchang, Yu Juehua, Niu Yuyu, Qin Dongdong, Liu Hailiang, Li Gang, Hu Yingzhou, Wang Jiaojian, Lu Yi, Kang Yu, Jiang Yong, Wu Kunhua, Li Siguang, Wei Jingkuan, He Jing, Wang Junbang, Liu Xiaojing, Luo Yuping, Si Chenyang, Bai Raoxian, Zhang Kunshan, Liu Jie, Huang Shaoyong, Chen Zhenzhen, Wang Shuang, Chen Xiaoying, Bao Xinhua, Zhang Qingping, Li Fuxing, Geng Rui, Liang Aibin, Shen Dinggang, Jiang Tianzi, Hu Xintian, Ma Yuanye, Ji Weizhi, Sun Yi Eve
Abstract excerpt
Gene-editing technologies have made it feasible to create nonhuman primate models for human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelopmental disorder, Rett syndrome (RTT), which is caused by loss-of-function mutations in the human MECP2 gene. Male mutant monkeys were embryonic lethal, reiterating that...
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