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Article

Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction.

The Journal of biological chemistry - 1 Mar 2025

Biswas Soumi, Lee Ji-Eun, Xie Guojia, Masclef Louis, Ren Zhizhong, Côté Jacques, Affar El Bachir, Ge Kai, Kutateladze Tatiana G

Abstract excerpt

Human additional sex combs like (ASXL) proteins are involved in the maintenance of both transcriptional activation and repression through their ability to bind multiple chromatin regulators, including two tumor suppressors: deubiquitinase BAP1 and methyltransferase MLL4 (KMT2D). The ASXL genes are often altered in colorectal cancer (CRC), and ASXL1 is one of the four hub genes related to the pathogenesis of CRC....

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Topics

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Share to Colorectal Neoplasms
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HCT116 Cells

Share to Histone-Lysine N-Methyltransferase

Share to Promoter Regions, Genetic

Share to Repressor Proteins

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 39984049
DOI: 10.1016/j.jbc.2025.108333
PMCID: PMC11957774

Genes

BAP1
ASXL1
KMT2D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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