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Article

The Wnt antagonist sFRP1 in colorectal tumorigenesis.

Cancer research - 1 Feb 2004

Caldwell Germaine M, Jones Carolyn, Gensberg Karl, Jan Shamem, Hardy Robert G, Byrd Philip, Chughtai Shaheen, Wallis Yvonne, Matthews Glenn M, Morton Dion G

Abstract excerpt

Regions of the short arm of chromosome 8 are deleted frequently in a range of solid tumors, indicating that tumor suppressor genes reside at these loci. In this study, we have examined the properties of the Wnt signaling antagonist secreted frizzled-related protein (sFRP) 1 as a candidate for this role at c8p11.2. An initial survey of 10 colorectal tumors, selected by the presence of isolated short deletions of...

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Identifiers

PMID: 14871816
DOI: 10.1158/0008-5472.can-03-1346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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