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Article

Colorectal cancer epigenetics: complex simplicity.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2011

van Engeland Manon, Derks Sarah, Smits Kim M, Meijer Gerrit A, Herman James G

Abstract excerpt

Colorectal cancer (CRC) has predominantly been considered a genetic disease, characterized by sequential accumulation of genetic alterations. Growing evidence indicates that epigenetic alterations add an additional layer of complexity to the pathogenesis of CRC, and characterize a subgroup of colorectal cancers with a distinct etiology and prognosis. Epigenetic dysregulation in colorectal cancer is organized at...

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Identifiers

PMID: 21220596
DOI: 10.1200/JCO.2010.28.2319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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