Article
Lon protease affects the RdxA nitroreductase activity and metronidazole susceptibility in Helicobacter pylori.
Helicobacter - 1 Oct 2014
Tu I-Fan, Liao Jiahn-Haur, Yang Feng-Ling, Lin Nien-Tsung, Chan Hong-Lin, Wu Shih-Hsiung
Abstract excerpt
BACKGROUND: The lon gene of Helicobacter pylori strains is constitutively expressed during growth. However, virtually nothing is understood concerning the role of Lon in H. pylori. This study examined the function and physiological role of Lon in H. pylori (HpLon) using a trapping approach to identify putative Lon binding partners in the bacterium. MATERIALS AND METHODS: Protease-deficient Lon was expressed and...
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