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Article

Role of the rdxA and frxA genes in oxygen-dependent metronidazole resistance of Helicobacter pylori.

Journal of medical microbiology - 1 Nov 2004

Gerrits Monique M, van der Wouden Egbert-Jan, Bax Dorine A, van Zwet Anton A, van Vliet Arnoud Hm, de Jong Albertine, Kusters Johannes G, Thijs Jaap C, Kuipers Ernst J

Abstract excerpt

Almost 50 % of all Helicobacter pylori isolates are resistant to metronidazole, which reduces the efficacy of metronidazole-containing regimens, but does not make them completely ineffective. This discrepancy between in vitro metronidazole resistance and treatment outcome may partially be explained by changes in oxygen pressure in the gastric environment, as metronidazole-resistant (MtzR) H. pylori isolates...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15496391
DOI: 10.1099/jmm.0.45701-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of the rdxA and frxA genes in oxygen-dependent metronidazole resistance of Helicobacter pylori.PMID 15496391Read ↗

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Roles of FrxA and RdxA Nitroreductases of <i>Helicobacter pylori</i> in Susceptibility and Resistance to MetronidazoleSemantic proximity Read ↗

Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.Semantic proximity Read ↗

Genetic analysis of Helicobacter pylori clinical isolates suggests resistance to metronidazole can occur without the loss of functional rdxA.Semantic proximity Read ↗

A redox basis for metronidazole resistance in Helicobacter pylori.Semantic proximity Read ↗

Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance.Semantic proximity Read ↗

rdxA, frxA, and efflux pump in metronidazole-resistant Helicobacter pylori: Their relation to clinical outcomes.Semantic proximity Read ↗

Oxygen scavenging, NADH oxidase and metronidazole resistance in Helicobacter pylori.Semantic proximity Read ↗

Alterations in rdxA and frxA genes and their upstream regions in metronidazole-resistant Helicobacter pylori isolates.Semantic proximity Read ↗

Analysis of <i>rdxA</i> and Involvement of Additional Genes Encoding NAD(P)H Flavin Oxidoreductase (FrxA) and Ferredoxin-Like Protein (FdxB) in Metronidazole Resistance of <i>Helicobacter pylori</i>Semantic proximity Read ↗

Sequential Inactivation of <i>rdxA</i> (HP0954) and <i>frxA</i> (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in <i>Helicobacter pylori</i>Semantic proximity Read ↗

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