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Article

Two amino acids mutation of ferric uptake regulator determines Helicobacter pylori resistance to metronidazole.

Antioxidants & redox signaling - 1 Jan 2011

Tsugawa Hitoshi, Suzuki Hidekazu, Satoh Kazue, Hirata Kenro, Matsuzaki Juntaro, Saito Yoshimasa, Suematsu Makoto, Hibi Toshifumi

Abstract excerpt

Metronidazole (Mtz) is a prodrug that is converted to its active form when its nitro group is reduced and superoxide radicals are generated. The superoxide radicals are directly toxic to the bacterium. On the other hand, the transcriptional regulator, ferric uptake regulator (Fur), of Helicobacter pylori is a direct suppressor of the iron-cofactored superoxide dismutase SodB, which is essential for protection...

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Identifiers

PMID: 20518707
DOI: 10.1089/ars.2010.3146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two amino acids mutation of ferric uptake regulator determines Helicobacter pylori resistance to metronidazole.PMID 20518707Read ↗

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The Ferric Uptake Regulator of Helicobacter Pylori : a Critical Player in the Battle for Iron and Colonization of the StomachSemantic proximity Read ↗

Iron-Responsive Regulation of the<i>Helicobacter pylori</i>Iron-Cofactored Superoxide Dismutase SodB Is Mediated by FurSemantic proximity Read ↗

Proteomic analysis of a ferric uptake regulator mutant of Helicobacter pylori: regulation of Helicobacter pylori gene expression by ferric uptake regulator and iron.Semantic proximity Read ↗

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