Sequential Inactivation of <i>rdxA</i> (HP0954) and <i>frxA</i> (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in <i>Helicobacter pylori</i>

Abstract excerpt

Helicobacter pylori is a human-pathogenic bacterial species that is subdivided geographically, with different genotypes predominating in different parts of the world. Here we test and extend an earlier conclusion that metronidazole (Mtz) resistance is due to mutation in rdxA (HP0954), which encodes a nitroreductase that converts Mtz from prodrug to bactericidal agent. We found that (i) rdxA genes PCR amplified...

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