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Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.

Molecular microbiology - 1 Apr 1998

Goodwin A, Kersulyte D, Sisson G, Veldhuyzen van Zanten S J, Berg D E, Hoffman P S

Abstract excerpt

Metronidazole (Mtz) is a critical component of combination therapies that are used against Helicobacter pylori, the major cause of peptic ulcer disease. Many H. pylori strains are Mtz resistant (MtzR), however, and here we show that MtzR results from loss of oxygen-insensitive NADPH nitroreductas...

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Identifiers

PMID: 9622362
DOI: 10.1046/j.1365-2958.1998.00806.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9622362-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.PMID 9622362Read ↗

Sequential Inactivation of <i>rdxA</i> (HP0954) and <i>frxA</i> (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in <i>Helicobacter pylori</i>Semantic proximity Read ↗

Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistance.Semantic proximity Read ↗

Genetic analysis of Helicobacter pylori clinical isolates suggests resistance to metronidazole can occur without the loss of functional rdxA.Semantic proximity Read ↗

Metronidazole resistance in Helicobacter pylori.Semantic proximity Read ↗

Roles of FrxA and RdxA Nitroreductases of <i>Helicobacter pylori</i> in Susceptibility and Resistance to MetronidazoleSemantic proximity Read ↗

Potential involvement of several nitroreductases in metronidazole resistance in Helicobacter pylori.Semantic proximity Read ↗

Analysis of <i>rdxA</i> and Involvement of Additional Genes Encoding NAD(P)H Flavin Oxidoreductase (FrxA) and Ferredoxin-Like Protein (FdxB) in Metronidazole Resistance of <i>Helicobacter pylori</i>Semantic proximity Read ↗

Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in <i>Helicobacter pylori</i> and in <i>Escherichia coli</i> Containing a Cloned <i>H. pylori rdxA</i> <sup>+</sup> (Nitroreductase) GeneSemantic proximity Read ↗

Analysis of allelic variants of rdxA associated with metronidazole resistance in Helicobacter pylori: detection of common genotypes in rdxA by multiplex allele-specific polymerase chain reaction.Semantic proximity Read ↗

Role of the rdxA and frxA genes in oxygen-dependent metronidazole resistance of Helicobacter pylori.Semantic proximity Read ↗

Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance.Semantic proximity Read ↗

Insertion of mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637.Semantic proximity Read ↗

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