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Article

Dissecting the Molecular Pathway Involved in PLK2 Kinase-mediated α-Synuclein-selective Autophagic Degradation.

The Journal of biological chemistry - 3 Mar 2017

Dahmene Manel, Bérard Morgan, Oueslati Abid

Abstract excerpt

Increasing lines of evidence support the causal link between α-synuclein (α-syn) accumulation in the brain and Parkinson's disease (PD) pathogenesis. Therefore, lowering α-syn protein levels may represent a viable therapeutic strategy for the treatment of PD and related disorders. We recently described a novel selective α-syn degradation pathway, catalyzed by the activity of the Polo-like kinase 2 (PLK2), capable...

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Identifiers

PMID: 28154193
DOI: 10.1074/jbc.M116.759373
PMCID: PMC5339772

Genes

PLK2
PLK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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