Article
MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of β-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer.
Carcinogenesis - 1 Oct 2014
Lin Po-Lin, Wu De-Wei, Huang Chi-Chou, He Tsung-Ying, Chou Ming-Chih, Sheu Gwo-Tarng, Lee Huei
Abstract excerpt
MiR-21 has been associated with poor prognosis in colon adenocarcinomas. However, in our preliminary data, the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli (APC)-mutated tumours, not in APC-wild-type tumours. We explored whether β-catenin nuclear translocation...
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