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Article

Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma.

The Journal of allergy and clinical immunology - 1 Oct 2014

Biagini Myers Jocelyn M, Martin Lisa J, Kovacic Melinda Butsch, Mersha Tesfaye B, He Hua, Pilipenko Valentina, Lindsey Mark A, Ericksen Mark B, Bernstein David I, LeMasters Grace K, Lockey James E, Khurana Hershey Gurjit K

Abstract excerpt

BACKGROUND: Epithelial genes have previously been associated with asthma but only explain a small fraction of heritability. In part, this might be due to epistasis, which is often not considered. OBJECTIVE: We sought to determine independent and epistatic associations between filaggrin (FLG), serine protease inhibitor Kazal-type 5 (SPINK5), and thymic stromal lymphopoietin (TSLP) gene variants and childhood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24831437
DOI: 10.1016/j.jaci.2014.03.037
PMCID: PMC4186896

Genes

SPINK5
TSLP
FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma.PMID 24831437Read ↗

Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample.Semantic proximity Read ↗

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.Semantic proximity Read ↗

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Thymic Stromal Lymphopoietin (TSLP) gene variant rs1837253 is significantly associated with Asthma prevalence in Pakistani Pashtun women.Semantic proximity Read ↗

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