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Thymic Stromal Lymphopoietin (TSLP) gene variant rs1837253 is significantly associated with Asthma prevalence in Pakistani Pashtun women.

Pakistan journal of pharmaceutical sciences - 1 Nov 2020

Afzal Sibtain, Ramzan Khushnooda, Khan Ihsanullah, Ullah Anhar, Tahir Asma I, Ramzan Shaiqa, Ullah Sajjad, Jamal Arshad, Absar Muhammad, Basit Sulman, Waqar Ahmed Bilal

Abstract excerpt

Asthma is a chronic inflammatory disease of the airways characterized by airway hyperresponsiveness and remodeling. Thymic stromal lymphopoietin (TSLP), a member of the interleukin-2 family of cytokines, is produced by activated lung and intestinal epithelial cells, mast, and other immune cells. Population-based studies identified associations between SNPs in the TSLP promoter region and asthma pathogenesis. In...

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PMID: 33879431

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