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Article

Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma

26 Apr 2022

Abstract excerpt

BACKGROUND: Clinical studies of type 2 (T2) cytokine-related neutralizing antibodies in asthma have identified a substantial subset of patients with low levels of T2 inflammation who do not benefit from T2 cytokine neutralizing antibody treatment. Non-T2 mechanisms are poorly understood in asthma but represent a redefined unmet medical need. OBJECTIVE: We sought to gain a better understanding of genetic...

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PMID: 35487308
DOI: 10.1016/j.jaci.2022.03.033

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